For Debbie 2/10/2018

I have had a few days off this week due to mechanical issues so I am trying to figure out what I can do to get the message through to people that the medical situation my wife is in IS a life or death situation. The only sure fix is a kidney transplant for which I am desperately searching. So I kept thinking what more could I do, what more has to be said about this. the answer came to me, NOTHING. I have said all I can and done everything that God has led me to do. Then God spoke to me and said “Gerry there is definitely more that you can do”. so feeling bewildered, upset, and confused I sat down, turned on the television and saw the answer. One of the reasons that people are so leery to help my wife might just be that they don’t know her very well at all. Well here are a few facts about my wife that might just help.

Debbie’s age is 57 soon to be 58.
Debbie is 5 feet tall even.
Debbie has no siblings at all and she only has 6 cousins all of whom are either the wrong blood type or in to bad of health to be able to help her with donation.
Debbie is married of course to me. She is a faithful attendee at Flintwood Weselyn Church.
Debbie has one daughter Casey Dawn, stepdaughter Avalon Michelle and a stepson Joshua Michael.
Debbie’s only daughter also has Polycystic Kidney Disease.
Debbie has 3 grandchildren Jaden, Kellan, and Aedyn.
Debbie is in excellent health with the exception of the Polycystic Kidney Disease that is trying to kill her.
Debbie has never smoked in her life.
Debbie has never ever done any illegal drugs.
Debbie doesn’t drink.
She is very protective of all living creatures.
She loves animals but her favorite are cats.
So, these are a few facts about my loving wife and believe me when I say this, I have done everything I can to donate one of my kidneys but Indiana University Health refused to let me. I am finishing this post with a short video I put together to further get you acquainted with my best friend in the whole world. Remember, dialysis is a short term fix and it shortens her life. The best possible scenario is for a live donor to come forth. It must be someone who is altruistic at heart. If you are in the slightest bit interested in being a living donor for Debbie and you have type “O” blood you must call Indiana University Transplant at 1-800-382-4602 and talk to Kelly. I have been told that she will discourage you from donating so unless you’re serious, please don’t call.

I’m Doing This For Debbie 1/28/2018


NEWSLETTER

HEALTH NEWS

Implantable Artificial Kidney Moves Closer to Reality
Written by Bob Curley on November 9, 2017

Scientists are developing an artificial kidney that can replicate the work of the real organs and potentially eliminate the need for dialsis.
Researchers at the University of California, San Francisco (UCSF), are developing an implantable artificial kidney that can closely replicate the functions of real kidneys.

If they are successful, the scientists’ work could help eliminate the need for dialysis.

Kidney transplants for patients with end-stage renal disease (ESRD) have a high rate of success.

About 93 percent of transplanted kidneys are still working after a year and 83 percent are functioning after three years.

But while more than 25,000 kidneys are transplanted each year, as of early 2016, more than 100,000 people were on the transplant waiting list in the United States.

Patients commonly wait five to 10 years for a suitable organ to become available.

Average life expectancy for dialysis patients is five to 10 years, although some have lived for decades.

However, dialysis — which filters out some (but not all) toxins from the bloodstream that would normally be eliminated by the kidneys — must be performed on a daily basis if done at home via peritoneal dialysis.

It requires three visits to a clinic weekly if performed via hemodialysis.

“The implantable bioartificial kidney is an alternative to dialysis and other externally wearable devices that would tether patients or limit their mobility,” Shuvo Roy, a professor in the UCSF Department of Bioengineering and Therapeutic Sciences and co-inventor of the device, told Healthline. “A live kidney transplant from a matching donor is still considered one of the best treatment options for ESRD, but unfortunately, there is shortage of organ donors that prevents transplants from being available to the vast majority of ESRD patients. Unlike transplants, our device will not require that patients be on immunosuppressive drugs to prevent rejection.”

Human trials of the device are about to begin.

Roy said the bioartificial kidney could eventually be used by the vast majority of the people now on dialysis and the kidney transplant list.

“This is a long-term solution, and any case where a kidney transplant is needed, our device will be a viable option,” said Roy.

How the device works
Roy leads The Kidney Project, a national research initiative centered on development and testing of a surgically implanted, freestanding bioartificial kidney that performs “the vast majority of the filtration, balancing, and other biological functions of the natural kidney.”

Powered by the body’s own blood pressure, the device does not require the external tubes or tethers associated with wearable artificial kidneys, such as that invented by Victor Gura of Cedars-Sinai Medical Center in Los Angeles. That device was tested on seven dialysis patients at the University of Washington Medical Center in Seattle in 2015.

The two-part implanted artificial kidney incorporates recent developments in silicon nanotechnology, which makes it possible to mass-produce reliable, robust, and compact filtering membranes.

The technology also has novel molecular coatings that protect the silicon membranes and make them blood-compatible.

“A hemofilter module processes incoming blood to create a watery ultrafiltrate that contains dissolved toxins as well as sugars and salts,” explained Roy. “Second, a bioreactor of kidney cells processes the ultrafiltrate and sends the sugars and salts back into the blood. In the process, water is also reabsorbed back into the body, concentrating the ultrafiltrate into ‘urine,’ which will be directed to the bladder for excretion.”

Patients with the implant may still be required to take hormonal supplements, however, as they currently do on dialysis, said Roy.

Development of alternatives to current treatments for kidney disease is “very important, since the outcomes of premature mortality and poor quality of life are common for the dialysis population, particularly for in-center hemodialysis,” Dr. Joseph Vassalotti, chief medical officer for the National Kidney Foundation, told Healthline.

The steps ahead
The Kidney Project is raising money to complete preclinical studies of the device modules and to build full-scale prototypes for the first round of human studies.

Initial clinical trials on the individual modules are expected to begin early next year.

Testing of a working prototype of the bioartificial kidney is slated for 2020.

“The long-term challenges center around keeping the device operating trouble-free after implantation beyond a few months,” said Roy. “Some problems won’t become clear until we do clinical trials.”

In addition to $6 million in government grants, the Kidney Project has received substantial donations from individuals in furtherance of its work to create an implantable artificial kidney.

“Their support is a testament to the acute need for a revolution in ESRD treatment, and the donations we have received are invaluable in allowing our research to progress,” said Roy.

In the future, scientists may be able to grow artificial kidneys.

In 2013, researchers, led by Melissa Little of the University of Queensland’s Institute for Molecular Bioscience, were able to grow a primitive kidney from human stem cells.

In 2016, researchers from the Salk Institute in California reported that they were able to grow nephron progenitor cells, which can differentiate into kidney tissue, in the lab.

Such research continues, but the ability to grow replacement organs remains a more distant dream than an implantable artificial kidney.

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